Recent Advances in Late-Stage Construction of Stapled Peptides via C−H Activation

Stapled peptides have been widely applied in many fields, including pharmaceutical chemistry, diagnostic reagents, and materials science. However, most traditional stapled peptide preparation methods rely on prefunctionalizations, which limit the diversity of stapled peptides. Recently, the emergence of late-stage transition metal-catalyzed C−H activation in amino acids and peptides has attracted wide interest due to its robustness and applicability for peptide stapling. In this review, we summarize the methods for late-stage construction of stapled peptides via transition metal-catalyzed C−H activation.     

Symmetry Breaking in Monometallic Nanocrystals toward Broadband and Direct Electron Transfer Enhanced Plasmonic Photocatalysis

Metallic nanocrystals manifest themselves as fascinating light absorbers for applications in plasmon-enhanced photocatalysis and solar energy harvesting. The essential challenges lie in harvesting the full-spectrum solar light and harnessing the plasmon-induced hot carriers at the metal–acceptor interface. To this end, a cooperative overpotential and underpotential deposition strategy is proposed to mitigate both the challenges. Specifically, by utilizing both ionic additive and thiol passivator to introduce symmetry-breaking growth over gold icosahedral nanocrystals, the microscopic origin can be attributed to the site-specific nucleation of stacking faults and dislocations. By adopting asymmetric crystal shape and unique surface facets, such nanocrystals attain high activity toward photocatalytic ammonia borane hydrolysis, arising from combined broadband plasmonic properties and enhanced direct transfer of hot electrons across the metal–adsorbate interface.     

Fabrication and characterizations of Cr3+-doped ZnGa2O4 transparent ceramics with persistent luminescence

0.5 at.% Cr:ZnGa₂O₄ precursor was synthesized by the co-precipitation method with nitrates as raw materials, using ammonium carbonate as the precipitant. Low-agglomerated Cr:ZnGa₂O₄ powders with an average particle size of 43 nm were obtained by calcining the precursor at 900℃ for 4 h. Using the powders as starting materials, 0.5 at.% Cr:ZnGa₂O₄ ceramics with an average grain size of about 515 nm were prepared by presintering at 1150℃ for 5 h in air and HIP post-treatment at 1100℃ for 3 h under 200 MPa Ar. The in-line transmittance of 0.5 at.% Cr:ZnGa₂O₄ ceramics with a thickness of 1.3 mm reaches 59.5% at the wavelength of 700 nm. The Cr:ZnGa₂O₄ ceramics can be effectively excited by visible light and produce persistent luminescence at 700 nm. For Cr:ZnGa₂O₄ transparent ceramics, the brightness of afterglow was larger than 0.32 mcd/m² after 30 min, which is far superior to that of Cr:ZnGa₂O₄ persistent luminescence powders.     

Features of crystal structures and thermo-mechanical properties of weberites RE3NbO7 (RE=La,Nd, Sm,Eu, Gd) ceramics

The features of crystal structures, thermo-mechanical properties and their dominant mechanisms of weberites RE₃NbO₇ were studied as high-temperature oxides. We concentrated on connections between structures and thermo-mechanical properties, the influences of bond lengths, lattice distortion degrees and microstructures on these properties were estimated. The shortening of bond length and increment of bonding strength would lead to the increase of mechanical properties. The Vickers hardness (4.5-7.8 GPa) and toughness (0.5-1.6 MPa·m^1/2) of weberites RE₃NbO₇ are enhanced by grain refinement and increment of bond strength, while crystal structures, bond lengths, and lattice distortion degrees influenced their Young's modulus (100-170 GPa). Nano-indentation was applied to test the influence of microstructures on modulus and hardness. The dominant mechanisms for mechanical properties and thermal conductivity were proposed, which was conducive to properties tailoring and engineering applications of weberites RE₃NbO₇ oxides.     

尽善尽美——儒家思想对中国设计的启示

经过几千年的发展和接受,儒家逐步确立了在中国主流意识形态中的“正典”地位。但应该承认,我们对于儒家的接受并不是不加批判全盘照搬的。在这两千多年的时间里,社会生活和意识形态领域所发生的重大变化我们不可能视而不见,而儒家思想恰恰有很大一部分是属于社会学科范畴之内的,在今天明显已经失去积极的意义(比如一些封建宗法),对此当然不能过分坚持,否定发展。因此,对于当今海外的“新儒家”的一些做法,可以欣赏他们对于中国传统文化的热忱,但必须承认那只是一部分知识分子的精英心态,从社会学的眼光看,的确过于保守,不利于文化的创造,特别是不能适应于现代艺术和设计的发展。本文希望区分出儒家思想中具有时代性和永恒性两个方面的内容,在对其已没有价值的社会伦理思想自觉进行发展的同时,对其永恒的东西进行一种当代的阐释。     

Multi-grained encoding and joint embedding space fusion for video and text cross-modal retrieval

Multimedia Tools and Applications - Video-text cross-modal retrieval is significant to computer vision. Most of existing works focus on exploring the global similarity between modalities, but...     

Research on Crop Irrigation Schedules Under Deficit Irrigation—A Meta-analysis

Water Resources Management - Increasing water consumption in agriculture due to global climate change has posed considerable challenges to food security, thus improving the efficiency of water...     

Effects of ultrasound-assisted resting on the qualities of whole wheat dough sheets and noodles

The effects of resting under ultrasonic treatment on the properties of whole wheat dough sheets and noodles were investigated. Compared with the control group, the resting time to reach the maximum breaking force and extensibility of whole wheat dough sheets treated with ultrasound was shortened by 20 min. The proportion of strongly bound water (T₂₁) decreased, while the proportion of weakly bound water (T₂₂) increased during resting, and the ultrasonic treatment could accelerate this moisture redistribution in the dough. The extent of the increase in gluten macropolymer and the decrease in –SH content of ultrasound-treated wheat dough was higher than that of the control one during the initial 5–15 min resting, which could be related to the improvement of whole wheat dough extensibility. Whole wheat noodles showed a better breaking distance for 10 min of ultrasonic-assisted resting. Ultrasonic treatment could be used to reduce the resting time of whole wheat dough sheets and improve the texture properties of noodles.     

探析信息化消防监督工作的措施

随着信息化技术的快速发展和成熟,信息化技术在各个领域中得到了广泛的应用,而消防监督也顺应时代发展,逐步将信息化技术应用于消防监督工作中.文章从消防监督信息化的现状出发,简要分析了消防监督信息化的功能定位和现阶段消防监督工作所存在的问题,并着重探究了信息化技术在消防监督工作中的应用策略.